Triethylamine → HCID 66940621, compound

HRID 1910220Notes

Reaction equation

HRID 1910220 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8](F)[CH:7]=[C:6]([NH2:11])[C:5]=1[N+:12]([O-:14])=[O:13].[CH2:16](N(CC)CC)C.[CH3:23][CH2:24][O-:25].[Na+]>C(O)C>[CH2:1]([O:2][C:3](=[O:15])[C:4]1[CH:9]=[C:8]([O:25][CH2:24][CH3:23])[CH:7]=[C:6]([NH2:11])[C:5]=1[N+:12]([O-:14])=[O:13])[CH3:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2723922Sodium ethoxideHCID 58724451Methyl 3-amino-5-fluoro-2-nitrobenzoate

Product 1

HCID 66940621HCID 66940621, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

5.0 g (23.3 mmol) of 3-amino-5-fluoro-2-nitro-benzoic acid methyl ester was dissolved in ethanol and treated with 2.6 g (25.6 mmol) of triethylamine and 1.8 g (25.6 mmol) of NaOEt. The reaction was heated at 60° C. for 0.5 h to produce 3-amino-5-ethoxy-2-nitro-benzoic acid ethyl ester. LCMS: 255 (M+1)+.

Sources & evidence

ORD record
ord-ec898d258d3e47a48989745cdd32cbe9
Source dataset
uspto-grants-2013_12
Patent number
US08598353B2

Reaction notes

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