2-Bromopyridine → 2-(3-Bromophenyl)pyridine

HRID 1910348Notes

Reaction equation

HRID 1910348 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.Br[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=1>>[Br:1][C:2]1[CH:7]=[C:6]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 2773294(2-Bromophenyl)boronic acid

Product 1

HCID 111155062-(3-Bromophenyl)pyridine

Procedure

2-bromophenylboronic acid (35.0 g, 0.174 mol) was reacted with 2-bromopyridine (55.1 g, 0.348 mol) under standard Suzuki coupling condition. The excess 2-bromopyridine was removed via vacuum distillation at 125° C. The product was collected at 180° C. as a light yellow liquid (29 g, 71%) and used for the next reaction without additional purification.

Workup

  1. customThe excess 2-bromopyridine was removed via vacuum distillation at 125° C
  2. customThe product was collected at 180° C. as a light yellow liquid (29 g, 71%)
  3. customused for the next reaction without additional purification

Sources & evidence

ORD record
ord-6ce7ed5acda24115b064c90767934736
Source dataset
uspto-grants-2013_12
Patent number
US08603645B2

Reaction notes

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