反应详情

45 mg (0.38 mmol) 4-hydroxymethylpyrrolidin-2-one was placed in 1 ml dimethylacetamide and 16 mg (0.29 mmol) sodium hydride (60%) were added and the mixture was stirred for 15 min at ambient temperature. Then 100 mg (0.34 mmol) of 6.1 was added and the mixture was stirred for 2 h at 50° C. and overnight at 25° C. The reaction mixture was purified by chromatography (RP-HPLC-MS). The corresponding fractions were freeze-dried.

1. stirringthe mixture was stirred for 2 h at 50° C. and overnight at 25° C
2. customThe reaction mixture was purified by chromatography (RP-HPLC-MS)
3. customThe corresponding fractions were freeze-dried