Hydrochloric Acid → 1-Cyclopropylpiperazine dihydrochloride

HRID 1911392Notes

Reaction equation

HRID 1911392 reaction equation
[ClH:1].O1CCOCC1.[CH:8]1([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH2:10][CH2:9]1>CO.C(OCC)(=O)C>[ClH:1].[ClH:1].[CH:8]1([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:10][CH2:9]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 20294524tert-Butyl 4-cyclopropylpiperazine-1-carboxylate

Product 1

HCID 212208121-Cyclopropylpiperazine dihydrochlorideYield 93%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

4.0M HCl in dioxane (42.7 mL, 170.78 mmol) was added to a stirred solution of tert-butyl 4-cyclopropylpiperazine-1-carboxylate (7.73 g, 34.16 mmol) in a mixture of methanol (50.0 mL) and ethyl acetate (200 mL). The resulting suspension was stirred at room temperature for 24 h under nitrogen. The white solid filtered off to give 1-cyclopropylpiperazine dihydrochloride (6.30 g, 93%).

Workup

  1. filtrationThe white solid filtered off

Sources & evidence

ORD record
ord-20f5cdec85454d5294f7347f81b50c71
Source dataset
uspto-grants-2013_12
Patent number
US08604022B2

Reaction notes

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