Chlorotrimethylsilane → HCID 86650528, compound

HRID 1911828Notes

Reaction equation

HRID 1911828 reaction equation
[CH2:1]([C@H:8]1[CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:20])[CH2:15][CH2:16][CH2:17][C:18]#[CH:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Mg+2].[Cl-].[CH2:24](N(CC)CC)C.[Cl:31][C:32]1[N:37]=[CH:36][C:35]([CH:38]=[O:39])=[CH:34][CH:33]=1.Cl[Si](C)(C)C>C(OCC)(=O)C>[CH2:1]([C@H:8]1[CH2:24][CH2:12][O:11][C:10](=[O:13])[N:9]1[C:14](=[O:20])[C@@H:15]([C@@H:38]([C:35]1[CH:36]=[N:37][C:32]([Cl:31])=[CH:33][CH:34]=1)[OH:39])[CH2:16][CH2:17][C:18]#[CH:19])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

7

Reactant 5

HCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 27640536-Chloropyridine-3-carbaldehydeHCID 5360315Magnesium ChlorideHCID 57907447HCID 57907447, compound

Product 1

HCID 86650528HCID 86650528, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of 23.0 g (837 mmol) of the title compound from step A above in 200 mL of anhydrous ethyl acetate at ambient temperature under an atmosphere of nitrogen was added 1.6 g (17 mmol) of anhydrous magnesium chloride, 23.0 mL (166 mmol) of triethylamine, 14.0 g (100 mmol) of 6-chloropyridine-3-carboxaldehyde and 16.0 mL (124 mmol) of chlorotrimethylsilane and the resulting mixture was stirred for 72 h. The heterogeneous reaction mixture was filtered through a 300 mL plug of silica gel eluting with an additional 1 L of ethyl acetate. The filtrate was evaporated to dryness in vacuo and the residue suspended in 200 mL of methanol and 5.0 mL of trifluoroacetic acid. The resulting mixture was stirred at ambient temperature under nitrogen for 5 h during which time the reaction became homogeneous. All volatiles were then removed in vacuo and the residue was purified by silica gel chromatography eluting with a 10-15% ethyl acetate in hexanes gradient to afford the title compound as a white solid (30 g, 88%). LC-MS: m/z (ES) 413.2 (MH)+.

Workup

  1. filtrationThe heterogeneous reaction mixture was filtered through a 300 mL plug of silica gel eluting with an additional 1 L of ethyl acetate
  2. customThe filtrate was evaporated to dryness in vacuo
  3. stirringThe resulting mixture was stirred at ambient temperature under nitrogen for 5 h during which time the reaction
  4. customAll volatiles were then removed in vacuo
  5. customthe residue was purified by silica gel chromatography
  6. washeluting with a 10-15% ethyl acetate in hexanes gradient

Sources & evidence

ORD record
ord-34f9dcdb1d8c4b25b3cc166a0df3e50b
Source dataset
uspto-grants-2013_12
Patent number
US08604038B2

Reaction notes

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