反应详情

温度

70 °C

3-(2,2-dimethylpropyl)-1-cyclobutenecarboxylic acid (10 g), tetrahydrofuran (100 mL) and 6 N hydrochloric acid (100 mL) were mixed. To the mixture was added zinc (30 g) at ice temperature. The mixture was stirred at 70° C. overnight. After an addition of 6 N hydrochloric acid and water the mixture was filtered. The filtrate was extracted with ethyl acetate (150 mL, 100 mL). The organic layer was washed with brine (100 mL), then dried over sodium sulfate. The sodium sulfate was filtered off and the filtrate was concentrated in vacuo to give the title compound (11.6 g) as a crude product.

1. filtrationwas filtered
2. extractionThe filtrate was extracted with ethyl acetate (150 mL, 100 mL)
3. washThe organic layer was washed with brine (100 mL)
4. dry with materialdried over sodium sulfate
5. filtrationThe sodium sulfate was filtered off
6. concentrationthe filtrate was concentrated in vacuo