反应详情

Methyl 3-(2-(dichlorophosphoryloxy)phenyl)propanoate, 81 (2.77 mmol) and L-alanine methyl ester hydrochloride (0.42 g, 2.77 mmol) were suspended in anhydrous dichloromethane (10 mL). Anhydrous triethylamine (0.37 mL, 2.77 mmol) and dichloromethane (5 mL) were added dropwise at −78° C. under nitrogen. Following the addition, the reaction mixture was slowly warmed to it and stirred overnight. The solvent was removed under reduced pressure; the solid was washed with anhydrous ether (20 mL×2), and filtered. The filtrate was concentrated to a residue to give crude product as an oil. Dilution with THF (2.77 mL) gave a 1 M solution, which was used in the following step without any further purification.

1. additionthe addition
2. temperaturethe reaction mixture was slowly warmed to it
3. customThe solvent was removed under reduced pressure
4. washthe solid was washed with anhydrous ether (20 mL×2)
5. filtrationfiltered
6. concentrationThe filtrate was concentrated to a residue
7. customto give crude product as an oil