HRID1912349

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7841

Allyl bromide

C3H5Br

HCID11430

Potassium Carbonate

CK2O3

结构：CCN(CC)C(=O)c1ccc(C(c2cccc(OC)c2)N2C3CCC2C2CCC3N2)cc1

HCID67237501

未命名化合物

PRODUCTS

生成物

结构：C=CCN1C2CCC1C1CCC2N1C(c1ccc(C(=O)N(CC)CC)cc1)c1cccc(OC)c1

HCID53258062

未命名化合物

收率 96%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

A mixture formed of the compound obtained in example 5.1 (0.98 mmoles), of allyl bromide (1.5 equivalents) and of anhydrous potassium carbonate (3 equivalents) in acetone (25 ml) is heated at reflux for 14 hours. At the end it is filtered and the filtrate is evaporated under vacuum. The compound 4-[(10-allyl-9,10-diazatricyclo[4.2.1.12,5]dec-9-yl)-(3-methoxyphenyl)methyl]-N,N-diethyl benzamide (light solid) is obtained.

WORKUP

后处理

temperatureis heated
temperatureat reflux for 14 hours
filtrationAt the end it is filtered
customthe filtrate is evaporated under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-db60b76b1b5d4a69a73f33faddbae21d
来源数据集: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08609659B2
来源说明: uspto-grants-2013_12

反应 SMILES

[CH:1]12[N:9]([CH:10]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=3)[C:11]3[CH:23]=[CH:22][C:14]([C:15]([N:17]([CH2:20][CH3:21])[CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=3)[CH:6]([CH2:7][CH2:8]1)[CH:5]1[NH:32][CH:2]2[CH2:3][CH2:4]1.[CH2:33](Br)[CH:34]=[CH2:35].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:35]([N:32]1[CH:2]2[CH:1]3[N:9]([CH:10]([C:24]4[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH3:31])[CH:25]=4)[C:11]4[CH:23]=[CH:22][C:14]([C:15]([N:17]([CH2:20][CH3:21])[CH2:18][CH3:19])=[O:16])=[CH:13][CH:12]=4)[CH:6]([CH:5]1[CH2:4][CH2:3]2)[CH2:7][CH2:8]3)[CH:34]=[CH2:33]