HCID 58293287, compound → HCID 58293366, compound

HRID 1912442Notes

Reaction equation

HRID 1912442 reaction equation
C[O:2][C:3]([C:5]1([CH2:10][CH2:11][CH2:12][NH:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:9][CH2:8][CH2:7][NH:6]1)=O>C1(C)C(C)=CC=CC=1>[CH2:14]([N:13]1[CH2:12][CH2:11][CH2:10][C:5]2([NH:6][CH2:7][CH2:8][CH2:9]2)[C:3]1=[O:2])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 58293287HCID 58293287, compound

Product 1

HCID 58293366HCID 58293366, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 2-(3-benzylaminopropyl)pyrrolidine-2-carboxylic acid methyl ester (133 mg) in xylene (1.5 ml) was stirred at 130° C. overnight. The mixture was cooled to room temperature, and purified by silica gel column chromatography (eluent: chloroform/methanol=10/1) to give the titled compound (90 mg).

Workup

  1. custompurified by silica gel column chromatography (eluent: chloroform/methanol=10/1)

Sources & evidence

ORD record
ord-8651ee871806468abf7db995e68525b6
Source dataset
uspto-grants-2013_12
Patent number
US08609647B2

Reaction notes

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