Diisopropylamine → 2-(4-Bromo-phenyl)-3-cyclopentyl-propionic acid

HRID 191256Notes

Reaction equation

HRID 191256 reaction equation
[Br:13][c:14]1[cH:15][cH:16][c:17]([CH2:20][C:21](=[O:22])[OH:23])[cH:18][cH:19]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH3:36][N:37]1[CH2:38][CH2:39][CH2:40][N:41]([CH3:42])[C:43]1=[O:44].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[I:24][CH2:25][CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1.[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[Br:13][c:14]1[cH:15][cH:16][c:17]([CH:20]([C:21](=[O:22])[OH:23])[CH2:25][CH:26]2[CH2:27][CH2:28][CH2:29][CH2:30]2)[cH:18][cH:19]1

Participants

7

Reactant 6

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 74654Benzeneacetic acid, 4-bromo-HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-HCID 2762531(Iodomethyl)cyclopentaneHCID 178418339Butyllithium

Product 1

HCID 223150942-(4-Bromo-phenyl)-3-cyclopentyl-propionic acid

Sources & evidence

ORD record
ord-35618092133d41c5b73a4adc54388ddd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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