反应详情

温度

50 °C

In 1 mL of dimethyl sulfoxide, 40 mg (0.07 mmol) of 1-[4-(4-cyano-imidazo[4,5-c]pyridin-1-yl)phenyl]-3-[3-(4-methylpiperazin-1-ylmethyl)-5-(trifluoromethyl)phenyl]urea was dissolved, and 40 μL (0.35 mmol) of a 30% hydrogen peroxide aqueous solution and 21 mg (0.15 mmol) of potassium carbonate were added thereto and the mixture solution was stirred at 50° C. for one hour. The reaction solution was partitioned between ethyl acetate and water, and the organic layer was washed with water and a saturated sodium chloride solution in the order named and concentrated under reduced pressure. The crude product was purified by a silica gel column (dichloromethane:methanol=10:1) to obtain 19 mg (45%) of a target product as a white solid.

1. customThe reaction solution was partitioned between ethyl acetate and water
2. washthe organic layer was washed with water
3. concentrationconcentrated under reduced pressure
4. customThe crude product was purified by a silica gel column (dichloromethane:methanol=10:1)