Thionyl Chloride → HCID 86665150, compound

HRID 1912894Notes

Reaction equation

HRID 1912894 reaction equation
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

Product 1

HCID 86665150HCID 86665150, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
22 °C

Procedure

To a mixture of the product from Example 4B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at 22° C. for 2 hours. The excess of thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

Workup

  1. customThe excess of thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-725e7c30827546548599d3f286001c5d
Source dataset
uspto-grants-2013_12
Patent number
US08609669B2

Reaction notes

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