反应详情

To a solution of 2-fluoro-3-methoxy-phenylboronic acid (10.0 g, 0.059 mol) in tetrahydrofuran (160 mL) was added glacial acetic acid (60 mL). The resulting mixture was cooled to 0° C. before hydrogen peroxide (50% aqueous solution, 8 mL) was added. The resulting mixture was allowed to come to room temperature and stirred for 65 h. The mixture was evaporated and the residue was dissolved in ethyl acetate, washed with hydrochloric acid (0.5N), water and brine. The organic phase was dried, filtered and evaporated which afforded 2-fluoro-3-methoxy-phenol (6.77 g, 81%) as a pale yellow oil.

1. additionwas added
2. customto come to room temperature
3. customThe mixture was evaporated
4. dissolutionthe residue was dissolved in ethyl acetate
5. washwashed with hydrochloric acid (0.5N), water and brine
6. customThe organic phase was dried
7. filtrationfiltered
8. customevaporated which