Ammonia → HCID 178490789, compound

HRID 1913128Notes

Reaction equation

HRID 1913128 reaction equation
[C:1]([NH:4][C@@H:5]1[CH2:10][CH2:9][C@H:8]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][C:21]=2[S:22](Cl)(=[O:24])=[O:23])[C:18](=[O:26])[N:17]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[CH:16]=[C:15]3[Cl:36])[CH2:7][CH2:6]1)(=[O:3])[CH3:2].[NH3:37]>C1COCC1>[Cl:36][C:15]1[C:14]2[C:19](=[CH:20][C:21]([S:22](=[O:24])(=[O:23])[NH2:37])=[C:12]([O:11][C@@H:8]3[CH2:9][CH2:10][C@H:5]([NH:4][C:1](=[O:3])[CH3:2])[CH2:6][CH2:7]3)[CH:13]=2)[C:18](=[O:26])[N:17]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[CH:16]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 178490790HCID 178490790, compound

Product 1

HCID 178490789HCID 178490789, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 29 mg of 6-(4-acetylamino-cis-cyclohexyloxy)-4-chloro-2-(4-methoxy-benzyl)-1-oxo-1,2-dihydro-isoquinoline-7-sulfonyl chloride (129, crude product) in 2 ml of THF 2 ml of 33% aqueous ammonia solution were added. After 1 h at room temperature the solvent was removed under reduced pressure and the crude product was used without further purification. Rt=1.22 min (Method C). Detected mass: 534.5 (M+H+).

Workup

  1. customAfter 1 h at room temperature the solvent was removed under reduced pressure
  2. customthe crude product was used without further purification

Sources & evidence

ORD record
ord-42dd1e2589ab4f129a216f4b9a6ec5c1
Source dataset
uspto-grants-2013_12
Patent number
US08609691B2

Reaction notes

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