Hydrochloric Acid → tert-Butyl 6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyridine-3-carboxylate hydrochloride

HRID 1913197Notes

Reaction equation

HRID 1913197 reaction equation
[O:1]=[C:2]1[N:6]([C:7]2[N:12]=[CH:11][C:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[CH:9][CH:8]=2)[NH:5][CH:4]=[C:3]1[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1.[ClH:26]>O1CCOCC1>[ClH:26].[O:1]=[C:2]1[N:6]([C:7]2[N:12]=[CH:11][C:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[CH:9][CH:8]=2)[NH:5][CH:4]=[C:3]1[C:20]1[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59280191HCID 59280191, compound

Product 1

HCID 86640854tert-Butyl 6-(5-oxo-4-pyridin-3-yl-2,5-dihydro-1H-pyrazol-1-yl)pyridine-3-carboxylate hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

100 mg (0.3 mmol) of the compound from Example 15 are stirred in a 4 N solution of hydrogen chloride in dioxane at RT for 30 min. The solid is then filtered off and dried under high vacuum.

Workup

  1. filtrationThe solid is then filtered off
  2. customdried under high vacuum

Sources & evidence

ORD record
ord-352601ddf2ab46cea4799d39295e9e83
Source dataset
uspto-grants-2013_12
Patent number
US08609698B2

Reaction notes

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