Hydrochloric Acid → HCID 68717438, compound

HRID 1913201Notes

Reaction equation

HRID 1913201 reaction equation
[C:1]([O:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17](=[O:18])[C:16]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:15][NH:14]2)=[N:11][CH:12]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:25]>O1CCOCC1>[ClH:25].[C:1]([O:5][CH2:6][C:7]1[CH:8]=[CH:9][C:10]([N:13]2[C:17](=[O:18])[C:16]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:15][NH:14]2)=[N:11][CH:12]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59280184HCID 59280184, compound

Product 1

HCID 68717438HCID 68717438, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

400 mg (1.2 mmol) of the compound from Example 20 are stirred in 20 ml of a 4 N solution of hydrogen chloride in dioxane at RT for 30 min. The solid is filtered off and dried under high vacuum. It is then dissolved in water, and the solution is lyophilized. The lyophilizate is once more stirred with 10 ml of a 4 N solution of hydrogen chloride in dioxane for 30 min. The solid is filtered off, washed once with tert-butyl methyl ether and dried under high vacuum.

Workup

  1. filtrationThe solid is filtered off
  2. customdried under high vacuum
  3. dissolutionIt is then dissolved in water
  4. filtrationThe solid is filtered off
  5. washwashed once with tert-butyl methyl ether
  6. customdried under high vacuum

Sources & evidence

ORD record
ord-b0afb485ea3e45be9157f07f629dc3e5
Source dataset
uspto-grants-2013_12
Patent number
US08609698B2

Reaction notes

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