Hydrochloric Acid → HCID 68716544, compound

HRID 1913203Notes

Reaction equation

HRID 1913203 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:14]([CH2:15][OH:16])=[CH:13][N:12]=[C:11]([N:17]2[C:21](=[O:22])[C:20]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[CH:19][NH:18]2)[CH:10]=1.Cl>O1CCOCC1>[ClH:8].[Cl:8][C:9]1[C:14]([CH2:15][OH:16])=[CH:13][N:12]=[C:11]([N:17]2[C:21](=[O:22])[C:20]([C:23]3[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=3)=[CH:19][NH:18]2)[CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68717571HCID 68717571, compound

Product 1

HCID 68716544HCID 68716544, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

12 mg (0.03 mmol) of the compound from Example 23 are stirred in 1.5 ml of a 4 N solution of hydrogen chloride in dioxane for 30 min. The mixture is then decanted, the residue is stirred in tert-butyl methyl ether and decanted off again, and the solid that remains is initially air-dried and then dried under high vacuum.

Workup

  1. customThe mixture is then decanted
  2. customdecanted off again
  3. customthe solid that remains is initially air-dried
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-3c03867f776a42c399329ebed47f072e
Source dataset
uspto-grants-2013_12
Patent number
US08609698B2

Reaction notes

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