Hydrochloric Acid → HCID 67409470, compound

HRID 1913440Notes

Reaction equation

HRID 1913440 reaction equation
C[O:2][C:3](=[O:17])[CH2:4][C:5]1[C:13](C([O-])=O)=[C:8]2[CH2:9][CH2:10][CH2:11][CH2:12][N:7]2[N:6]=1.[ClH:18]>>[ClH:18].[N:6]1[N:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C:8]2=[CH:13][C:5]=1[CH2:4][C:3]([OH:17])=[O:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86657725HCID 86657725, compound

Product 1

HCID 67409470HCID 67409470, compoundYield 88%

Procedure

The crude 2-(2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate (39 mg, 0.16 mmol) was suspended in concentrated HCl (5 mL) and was heated at reflux for 2 hours. The reaction was cooled and concentrated in vacuo to afford the title compound (30 mg, 88%). The material was used directly without further purification. MS (ES+) 181.2 (M+H)+. Retention time: 1.26 min XBridge C18 4.6×50 mm 5 um, 5-100% acetonitrile:water (0.1% formic acid).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-defd08e2eba544cba25ff314a4a557da
Source dataset
uspto-grants-2013_12
Patent number
US08609680B2

Reaction notes

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