反应详情

温度

110 °C

A solution of 450 mg (0.72 mmol) of methyl 4-[(4E)-3-(4-cyanobenzyl)-5-(2-{4-[4-(trifluoromethyl)phenoxy]butoxy}phenyl)pent-4-en-1-yl]benzoate in 15 ml of 1-propanol and 2 ml of water is mixed with 1207 mg (21.5 mmol) of potassium hydroxide and stirred at 110° C. for 12 h. After cooling, the mixture is acidified with 1 M hydrochloric acid, and the crystals which have separated out are filtered off with suction, washed several times with water and dried. 447 mg (0.65 mmol, 90% of theory, purity 92%) of the title compound are obtained.

1. temperatureAfter cooling
2. customthe crystals which have separated out
3. filtrationare filtered off with suction
4. washwashed several times with water
5. customdried