反应详情

A mixture of N-((S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2-yl)-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide (1.00 g), toluene (10 ml), Pd(PPh3)4 (26.7 mg) and allyltributyltin (2.46 g) was boiled at reflux for 5 hours. The cooled reaction mixture was diluted with ethyl acetate and washed with water. The organic phase was washed with sodium chloride solution, dried over sodium sulfate and concentrated. The residue was purified by chromatography on silica gel. The product was thus obtained with the molecular weight of 391.51 (C25H29NO3); MS (ESI): 392 (M+H+).

1. temperatureat reflux for 5 hours
2. customThe cooled reaction mixture
3. washwashed with water
4. washThe organic phase was washed with sodium chloride solution
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated
7. customThe residue was purified by chromatography on silica gel
8. customThe product was thus obtained with the molecular weight of 391.51 (C25H29NO3)