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HRID1913821

反应详情

EQUATION

反应方程式

HRID 1913821 的结构方程式

REACTANTS

反应物

3
结构：Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1
HCID466102

未命名化合物

结构：CC(C)(C)[S@](N)=O
HCID10964479

(R)-(+)-2-Methyl-2-propanesulfinamide

C4H11NOS

结构：O=Cc1ccc2c(c1)CC[C@H](NC(=O)c1ccc(OC[C@@H]3CCCO3)cc1)C2
HCID86762190

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[S@@](=O)/N=C/c1ccc2c(c1)CC[C@H](NC(=O)c1ccc(OC[C@@H]3CCCO3)cc1)C2
HCID87439525

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O=S(=O)([O-])[O-].[Cu+2]
催化剂HCID24462

Copper sulfate

CuO4S

结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A mixture of N-((S)-6-formyl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide (1.0 g), (R)-2-methylpropane-2-sulfinic acid amide (0.32 g), pyridinium para-toluenesulfonate (165 mg), copper(II) sulfate (1.0 g; anhydrous) and dichloromethane (10 ml) was stirred for 24 hours. Solid fractions were filtered off and the filtrate was concentrated. The residue was purified by chromatography on silica gel. The product was thus obtained with the molecular weight of 482.65 (C27H34N2O4S); MS (ESI): 483 (M+H+).

WORKUP

后处理

  1. filtrationSolid fractions were filtered off
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by chromatography on silica gel
  4. customThe product was thus obtained with the molecular weight of 482.65 (C27H34N2O4S)