2-Aminobenzyl alcohol → HCID 49780152, compound

HRID 1914531Notes

Reaction equation

HRID 1914531 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][OH:9].[Br:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH:14]=O>CC(O)C>[Br:10][C:11]1[CH:12]=[C:13]([CH:14]2[NH:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=3[CH2:8][O:9]2)[CH:16]=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 214392-Aminobenzyl alcoholHCID 765833-Bromobenzaldehyde

Product 1

HCID 49780152HCID 49780152, compoundYield 6.5%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 2-amino-benzenemethanol (0.073 mol) and 3-bromo-benzaldehyde (0.073 mol) in 2-propanol (100 mL) was stirred for 3 hours at rt. The solvent was evaporated. Part (3 g) of the residue (20.5 g) was crystallized from hexane. The precipitate was filtered off and dried, yielding 1.37 g of the desired product.

Workup

  1. customThe solvent was evaporated
  2. customPart (3 g) of the residue (20.5 g) was crystallized from hexane
  3. filtrationThe precipitate was filtered off
  4. customdried

Sources & evidence

ORD record
ord-4d316b75241541c79723d0a256e5f9a2
Source dataset
uspto-grants-2013_12
Patent number
US08614201B2

Reaction notes

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