HCID 52944272, compound → HCID 50899254, compound

HRID 1914742Notes

Reaction equation

HRID 1914742 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:15]=[CH:16][C:17]([O:38][C:39]([F:42])([F:41])[F:40])=[C:18]([NH:20][C:21]3[N:30]=[CH:29][C:28]4[CH2:27][CH2:26][C:25]5[C:31]([C:35]([NH2:37])=[O:36])=[N:32][N:33]([CH3:34])[C:24]=5[C:23]=4[N:22]=3)[CH:19]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>O1CCOCC1.Cl>[N:11]1([C:14]2[CH:15]=[CH:16][C:17]([O:38][C:39]([F:40])([F:41])[F:42])=[C:18]([NH:20][C:21]3[N:30]=[CH:29][C:28]4[CH2:27][CH2:26][C:25]5[C:31]([C:35]([NH2:37])=[O:36])=[N:32][N:33]([CH3:34])[C:24]=5[C:23]=4[N:22]=3)[CH:19]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

4

Reactant 1

HCID 52944272HCID 52944272, compound

Product 1

HCID 50899254HCID 50899254, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 8-[5-(4-t-butoxycarbonyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (94 mg, 0.16 mmol) in dioxane (3 ml), 4M HCl in dioxane (0.89 ml, 3.42 mmol) was added. The mixture was stirred at room temperature for 3 h. The solvent was removed under reduced pressure and the crude was diluted with Et2O and decanted, to give the final compound as a hydrochloride salt in quantitative yield.

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionthe crude was diluted with Et2O
  3. customdecanted

Sources & evidence

ORD record
ord-9d964e4ec5374e079ad51a0a121ac09a
Source dataset
uspto-grants-2013_12
Patent number
US08614220B2

Reaction notes

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