1-Methylpiperazine → 1-[2-Hydroxy-4-(4-methyl-piperazin-1-yl)-phenyl]-ethanone

HRID 1914749Notes

Reaction equation

F[C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[C:4]([OH:11])[CH:3]=1.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[OH:11][C:4]1[CH:3]=[C:2]([N:16]2[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH2:15]2)[CH:7]=[CH:6][C:5]=1[C:8](=[O:10])[CH3:9]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 27373264'-Fluoro-2'-hydroxyacetophenone

Product 1

HCID 594543571-[2-Hydroxy-4-(4-methyl-piperazin-1-yl)-phenyl]-ethanone

Procedure

1-(4-Fluoro-2-hydroxy-phenyl)-ethanone (4.5 g, 29.22 mmol) was treated with N-methylpiperazine (5 mL) at 130° C. for 3 h to give 1-[2-hydroxy-4-(4-methyl-piperazin-1-yl)-phenyl]-ethanone in quantitative yield.

Sources & evidence

ORD record: ord-acd59729dd6d4c71a9304419ebf93fd7
Source dataset: uspto-grants-2013_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08614220B2

Reaction notes

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