N-Iodosuccinimide → HCID 178433771, compound

HRID 1914835Notes

Reaction equation

HRID 1914835 reaction equation
[CH3:1][C:2]1[CH:21]=[C:5]2[N:6]=[CH:7][C:8]3[CH:13]=[C:12]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[C:11](=[O:20])[NH:10][C:9]=3[N:4]2[N:3]=1.[I:22]N1C(=O)CCC1=O>CN(C=O)C>[I:22][C:21]1[C:2]([CH3:1])=[N:3][N:4]2[C:9]3[C:8](=[CH:13][C:12]([C:14]4[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=4)=[C:11]([OH:20])[N:10]=3)[CH:7]=[N:6][C:5]=12

Participants

4

Reactant 2

HCID 120273N-IodosuccinimideHCID 136133166HCID 136133166, compound

Product 1

HCID 178433771HCID 178433771, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of Compound (1-3) (0.2 g, 0.73 mmol, 1 eq.) in DMF (10 mL) was added N-iodosuccinimide (0.18 g, 0.8 mmol, 1.1 eq.) and the mixture stirred for 2 hours and concentrated. The residue was purified by silica gel chromatography using CHCl3/MeOH (10%) as eluant to give Compound (17-1)

Workup

  1. concentrationconcentrated
  2. customThe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-928301c30efe4c1c8b4aba4476a1eec9
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

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