Phosphorus oxychloride → HCID 58034613, compound

HRID 1914837Notes

Reaction equation

HRID 1914837 reaction equation
[CH3:1][C:2]1[CH:22]=[C:5]2[N:6]=[C:7]([CH3:21])[C:8]3[CH:13]=[C:12]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[C:11](=O)[NH:10][C:9]=3[N:4]2[N:3]=1.O=P(Cl)(Cl)[Cl:25]>>[Cl:25][C:11]1[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:13][C:8]2[C:7]([CH3:21])=[N:6][C:5]3[N:4]([N:3]=[C:2]([CH3:1])[CH:22]=3)[C:9]=2[N:10]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 136133173HCID 136133173, compound

Product 1

HCID 58034613HCID 58034613, compound

Procedure

In a 20 mL scintillation vial Compound (19-1) (0.08 g, 0.275 mmol, 1.0 eq.) was heated with 2 mL of POCl3 at 80° C. for 2 hours. The reaction was cooled and concentrated and the residue by silica gel chromatography using CHCl3/MeOH (10%) as eluant to give Compound (19-2).

Workup

  1. temperatureThe reaction was cooled
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d7c827809a954340965a77a589b884ad
Source dataset
uspto-grants-2013_12
Patent number
US08614221B2

Reaction notes

Loading…