Diisopropylethylamine → HCID 86597653, compound

HRID 1914972Notes

Reaction equation

HRID 1914972 reaction equation
[CH3:1][N:2]([C:4]([O:8][N:9]1[N:17]=[N:16][C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]1=2)=[N+:5]([CH3:7])[CH3:6])[CH3:3].[F:18][P-:19]([F:24])([F:23])([F:22])([F:21])[F:20].CCN(C(C)C)C(C)C>CN1C(=O)CCC1>[CH3:7][N:5]([C:4]([O:8][N:9]1[N:17]=[N:16][C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]1=2)=[N+:2]([CH3:3])[CH3:1])[CH3:6].[F:18][P-:19]([F:24])([F:23])([F:22])([F:21])[F:20].[CH:13]1[CH:14]=[N:15][C:10]2[N:9]([OH:8])[N:17]=[N:16][C:11]=2[CH:12]=1

Participants

4

Reactant 2

HCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

Product 1

HCID 86597653HCID 86597653, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

A solution of Fmoc-Xaa-OH (2 eq.), HATU (2 eq.), HOAt (hydroxyazobenzotriazole) (2 eq.), DIEA (4 eq.) in NMP (1 ml/g resin) was added to the resin-bound peptides and shaken for 3 hours at room temperature and washed with NMP (5×).

Workup

  1. washwashed with NMP (5×)

Sources & evidence

ORD record
ord-87c6cb7a71ae43a08c1b3b419c5f61ab
Source dataset
uspto-grants-2013_12
Patent number
US08614290B2

Reaction notes

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