6-Bromohexanoic acid → HCID 178433620, compound

HRID 1914985Notes

Reaction equation

HRID 1914985 reaction equation
[CH3:1][C:2]1[C:3]([CH3:12])([CH3:11])[C:4]2[C:5]([N:10]=1)=[N:6][CH:7]=[CH:8][CH:9]=2.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>C(OCC)(=O)C>[Br-:13].[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][N:6]1[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH3:12])([CH3:11])[CH:2]([CH3:1])[NH+:10]=[C:5]12)([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 202106-Bromohexanoic acidHCID 222668362,3,3-Trimethyl-3H-pyrrolo[2,3-b]pyridine

Product 1

HCID 178433620HCID 178433620, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 0.54 g of 2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine and 1.32 g of 6-bromohexanoic acid is heated at 120° C. for one hour. Ethyl acetate (10 mL) is added, and the reaction mixture is heated at reflux for 15 minutes, then cooled to room temperature. The supernatant liquid is decanted to yield the product.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux for 15 minutes
  3. temperaturecooled to room temperature
  4. customThe supernatant liquid is decanted
  5. customto yield the product

Sources & evidence

ORD record
ord-930f2b60b49a47ae8d4deaa77b1eaaca
Source dataset
uspto-grants-2013_12
Patent number
US08614302B2

Reaction notes

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