反应详情

Methanol (5 mL) was added to a reaction vessel containing sorafenib free base (1.0 g), and the reaction mixture was stirred for about 5 minutes. Methanolic HCl (5 mL) was added gradually to the above reaction mixture at 0° C. The reaction mixture was stirred for about 1 hour. Diisopropyl ether (10 mL) was added. The reaction mixture was stirred for about 1 hour. The solid was filtered and dried under reduced pressure at about 50° C. for about 3 hours to obtain sorafenib hydrochloride.

1. stirringThe reaction mixture was stirred for about 1 hour
2. stirringThe reaction mixture was stirred for about 1 hour
3. filtrationThe solid was filtered
4. customdried under reduced pressure at about 50° C. for about 3 hours