反应详情

Methanol (35 mL) was added to a reaction vessel containing sorafenib free base (7.0 g) and the reaction mixture was stirred for about 5 minutes. Methanolic HCl (35 mL) was added drop-wise to the above reaction mixture at 0° C. The reaction mixture was stirred for about 1 hour. Diisopropyl ether (70 mL) was added. The reaction mixture was stirred for about 1 hour. The solid was filtered and dried under reduced pressure at about 50° C. for about 3 hours. The solid was triturated with toluene (20 mL) and the reaction mixture was concentrated. The solid was washed with toluene (2×20 mL) and dried under reduced pressure at about 30° C. for about 24 hours to obtain sorafenib hydrochloride.

1. stirringThe reaction mixture was stirred for about 1 hour
2. stirringThe reaction mixture was stirred for about 1 hour
3. filtrationThe solid was filtered
4. customdried under reduced pressure at about 50° C. for about 3 hours
5. customThe solid was triturated with toluene (20 mL)
6. concentrationthe reaction mixture was concentrated
7. washThe solid was washed with toluene (2×20 mL)
8. customdried under reduced pressure at about 30° C. for about 24 hours