反应详情

A mixture of 1-(3-(trifluoromethyl)phenyl)ethanone (25.0 g) (II), dimethylamine hydrochloride (13.0 g), paraformaldehyde (4.8 g), 31% w/w aqueous hydrochloric acid (0.5 mL) in ethanol (70 mL) was stirred at reflux temperature for 24 hrs, then cooled down and the solvent flushed with toluene (50 mL). The precipitated pale yellow solid was then filtrated, washed with toluene and dried to give the title compound (IV) (28.0 g).

1. temperatureat reflux temperature for 24 hrs
2. temperaturecooled down
3. customthe solvent flushed with toluene (50 mL)
4. filtrationThe precipitated pale yellow solid was then filtrated
5. washwashed with toluene
6. customdried