反应详情

温度

20 °C

To a solution containing (S)-2-[4-(3-dimethylamino-2-fluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid ethyl ester (0.261 g, 0.001 mol) in tetrahydrofuran (4 mL) was treated with an aqueous solution of lithium hydroxide monohydrate (0.5N, 2 mL, 0.001 mol). The mixture was stirred at 20° C. for 2 h, and the solvents evaporated. The residue was dried under high vacuum and rinsed with diethyl ether to afford (S)-2-[4-(3-dimethylamino-2-fluoro-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt (0.257 g, 100%) as a yellow solid.

1. customthe solvents evaporated
2. customThe residue was dried under high vacuum
3. washrinsed with diethyl ether