Diethyl phenylmalonate → HCID 178517378, compound

HRID 1915527Notes

Reaction equation

HRID 1915527 reaction equation
C(O[C:4](=[O:17])[CH:5]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:6]([O:8]CC)=O)C.S(O)(O)(=O)=O.[NH2:23][C:24]1[NH:25][CH:26]=[CH:27][N:28]=1.C1CCN2C(=NCCC2)CC1>CN(C=O)C>[C:11]1([C:5]2[C:4]([OH:17])=[N:23][C:24]3[N:25]([CH:26]=[CH:27][N:28]=3)[C:6]=2[OH:8])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 66514Diethyl phenylmalonateHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 135136Bis(2-amino-1H-imidazole) sulphate

Product 1

HCID 178517378HCID 178517378, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

18.3 g (0.0776 mol) diethylphenylmalonate and 20.5 g (0.0776 mol) 2-aminoimidazole sulfate are dissolved in 93 ml DMF and 35 ml DBU and the mixture heated to 100° C. for 15 h. The solvent is removed, the residue dissolved in water and re-precipitated by adjusting the pH to 1 with 2 mol/l HCl. The precipitate is collected by filtration to obtain the desired product.

Workup

  1. customThe solvent is removed
  2. dissolutionthe residue dissolved in water
  3. customre-precipitated
  4. filtrationThe precipitate is collected by filtration

Sources & evidence

ORD record
ord-d0921d428ceb476c9e9636e1968eb42b
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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