Guanidine Hydrochloride → HCID 68463935, compound

HRID 1915544Notes

Reaction equation

HRID 1915544 reaction equation
[CH3:1][O:2][CH:3]([O:19][CH3:20])[C:4]1[CH:9]=[CH:8][C:7]([CH:10](O)[CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:6][CH:5]=1.Cl.[NH2:22][C:23]([NH2:25])=[NH:24].[CH3:26][O-].[Na+]>CO>[CH3:1][O:2][CH:3]([O:19][CH3:20])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:26][N:22]=[C:23]([NH2:25])[N:24]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 5742Guanidine HydrochlorideHCID 10942334Sodium MethoxideHCID 67027749HCID 67027749, compound

Product 1

HCID 68463935HCID 68463935, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5 g of the product of step 1 and 3 g guanidine hydrochloride are dissolved in 100 ml methanol and 2.7 g of NaOMe is added. The mixture is heated to reflux for 17 h. The product is precipitated upon dilution of the mixture with water and is collected by filtration and washed twice with water.

Workup

  1. temperatureThe mixture is heated
  2. temperatureto reflux for 17 h
  3. customThe product is precipitated upon dilution of the mixture with water
  4. filtrationis collected by filtration
  5. washwashed twice with water

Sources & evidence

ORD record
ord-06bdbd254c7e430e9defd9888fb2fd55
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

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