Chlorosuccinimide → HCID 86630674, compound

HRID 1915564Notes

Reaction equation

HRID 1915564 reaction equation
[ClH:1].[C:2]1([C:8]2[C:9]([C:17]3C=CC(CN4CCC(C5N=C(C6C=CC=CN=6)NN=5)CC4)=[CH:19][CH:18]=3)=[N:10][C:11]3[N:12]([N:14]=[CH:15][CH:16]=3)[CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClN1[C:46](=[O:47])[CH2:45][CH2:44][C:43]1=O>C(Cl)(Cl)Cl>[Cl:1][C:16]1[CH:15]=[N:14][N:12]2[CH:13]=[C:8]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[C:9]([C:17]3[CH:43]=[CH:44][C:45]([CH:46]=[O:47])=[CH:19][CH:18]=3)=[N:10][C:11]=12

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 178477949HCID 178477949, compound

Product 1

HCID 86630674HCID 86630674, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

0.4 g 6-phenylpyrazolo[1,5-a]pyrimidin-5-yl)benzaldehyde (prepared as described under example 19) and 0.19 g N-chlorosuccinimide are refluxed in 10 ml chloroform for 5 d. The solvent is removed by distillation and the crude product is purified by chromatography on silica gel (dichloromethane/ethyl acetate).

Workup

  1. customThe solvent is removed by distillation
  2. customthe crude product is purified by chromatography on silica gel (dichloromethane/ethyl acetate)

Sources & evidence

ORD record
ord-d08a361910614173bec5527dcb206332
Source dataset
uspto-grants-2013_12
Patent number
US08614218B2

Reaction notes

Loading…