Dimethylformamide → N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 191577Notes

Reaction equation

HRID 191577 reaction equation
[CH3:25][c:26]1[c:27](-[n:32]2[c:33](=[O:41])[c:34]([C:38](=[O:39])[OH:40])[cH:35][cH:36][cH:37]2)[cH:28][cH:29][cH:30][cH:31]1.[CH3:75][N:76]([CH3:77])[CH:78]=[O:79].[CH:42]([N:43]([CH2:44][CH3:45])[CH:46]([CH3:47])[CH3:48])([CH3:49])[CH3:50].[NH2:1][c:2]1[cH:3][c:4]([F:24])[c:5]([O:6][c:7]2[cH:8][cH:9][c:10]3[n:11]([cH:12]2)[cH:13][c:14]([NH:16][C:17](=[O:18])[CH:19]2[CH2:20][CH2:21]2)[n:15]3)[cH:22][cH:23]1.[P-:51]([F:52])([F:53])([F:54])([F:55])([F:56])[F:57].[n:58]1([O:59][C:60]([N:61]([CH3:62])[CH3:63])=[N+:64]([CH3:65])[CH3:66])[c:67]2[n:68][cH:69][cH:70][cH:71][c:72]2[n:73][n:74]1>>[NH:1]([c:2]1[cH:3][c:4]([F:24])[c:5]([O:6][c:7]2[cH:8][cH:9][c:10]3[n:11]([cH:12]2)[cH:13][c:14]([NH:16][C:17](=[O:18])[CH:19]2[CH2:20][CH2:21]2)[n:15]3)[cH:22][cH:23]1)[C:38]([c:34]1[c:33](=[O:41])[n:32](-[c:27]2[c:26]([CH3:25])[cH:31][cH:30][cH:29][cH:28]2)[cH:37][cH:36][cH:35]1)=[O:39]

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 581585982-oxo-1-(o-tolyl)-1,2-Dihydropyridine-3-carboxylic acidHCID 58158605N-[6-(4-amino-2-fluorophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Product 1

HCID 58158454N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-1-(2-methylphenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-ef54fe50067540919ef86f07de4505e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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