Trifluoroacetic acid → HCID 86638311, compound

HRID 1916028Notes

Reaction equation

HRID 1916028 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([N:19]([CH2:31][C:32]([OH:34])=[O:33])[CH2:20][CH2:21][N:22]([CH2:27][C:28]([OH:30])=[O:29])[CH2:23][C:24]([OH:26])=[O:25])[CH2:9][N:10]([CH2:15][C:16]([OH:18])=[O:17])[CH2:11][C:12]([OH:14])=[O:13].C(OC([NH:42][CH2:43][CH:44]1[CH2:49][CH2:48][CH:47]([CH2:50][NH-:51])[CH2:46][CH2:45]1)=O)(C)(C)C>C(OCC)C>[CH2:20]([N:19]([CH2:31][C:32]([OH:34])=[O:33])[CH2:8][CH2:9][N:10]([CH2:11][C:12]([OH:14])=[O:13])[CH2:15][C:16]([OH:18])=[O:17])[CH2:21][N:22]([CH2:27][C:28]([OH:30])=[O:29])[CH2:23][C:24]([OH:26])=[O:25].[NH2:42][CH2:43][CH:44]1[CH2:49][CH2:48][CH:47]([CH2:50][NH-:51])[CH2:46][CH2:45]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86638312HCID 86638312, compound

Product 1

HCID 86638311HCID 86638311, compoundYield 141.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Subsequently, 95 ml of trifluoroacetic acid (produced by Wako Pure Chemical Industries, Ltd.) was added to 9.22 g of the DTPA-mono-(4-(N-tert-butoxycarbonylaminomethyl)cyclohexyl)methylamide obtained above, and, after stirring the mixture for 3 hours, the reaction mixture was added dropwise to diethyl ether to precipitate the reaction product. The reaction product precipitated was collected by suction filtration, and was dried under a reduced pressure, to obtain 11.0 g of DTPA-mono-(4-(aminomethyl)cyclohexyl)methylamide as the objective compound.

Workup

  1. customobtained above, and,
  2. customto precipitate the reaction product
  3. customThe reaction product precipitated
  4. filtrationwas collected by suction filtration
  5. customwas dried under a reduced pressure

Sources & evidence

ORD record
ord-fb956fc8bcd5488da9fb4f0d9f787de5
Source dataset
uspto-grants-2013_12
Patent number
US08618032B2

Reaction notes

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