Potassium Carbonate → HCID 58072595, compound

HRID 1916182Notes

Reaction equation

HRID 1916182 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[C:8]([C:9]#[C:10][Si](C)(C)C)=[CH:7][N:6]=[C:5]([NH2:15])[CH:4]=1.C([O-])([O-])=O.[K+].[K+]>CO>[C:9]([C:8]1[C:3]([C:2]([F:17])([F:1])[F:16])=[CH:4][C:5]([NH2:15])=[N:6][CH:7]=1)#[CH:10]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58072870HCID 58072870, compound

Product 1

HCID 58072595HCID 58072595, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The title compound is synthesized according to general procedure GP3 starting from 5.9 g (22.6 mmol) 4-trifluoromethyl-5-trimethylsilanylethynyl-pyridin-2-ylamine and 1.56 g (11.3 mmol) K2CO3 in 50 mL MeOH. The product is purified by chromatography on silica gel using a DCM/MeOH gradient. Yield: 2.97 g (71%).

Workup

  1. customThe product is purified by chromatography on silica gel using a DCM/MeOH gradient

Sources & evidence

ORD record
ord-ada1743c50784770babf4b6073133e5a
Source dataset
uspto-grants-2013_12
Patent number
US08618111B2

Reaction notes

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