Acetic Acid → HCID 178510542, compound

HRID 1916266Notes

Reaction equation

HRID 1916266 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.[NH:9]1[CH:13]=[CH:12][C:11]([CH:14]=O)=[N:10]1.[C:16]([CH2:18][C:19](=[S:21])N)#[N:17].C(O)(=O)C>CC(O)C>[O:8]=[C:4]1[NH:5][CH:6]=[CH:7][C:2]2[N:1]=[C:19]([SH:21])[C:18]([C:16]#[N:17])=[C:14]([C:11]3[CH:12]=[CH:13][NH:9][N:10]=3)[C:3]1=2

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 5735304-Amino-1,2-dihydropyridin-2-oneHCID 14162772-CyanoethanethioamideHCID 122183831H-Pyrazole-3-carbaldehyde

Product 1

HCID 178510542HCID 178510542, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

573 mg (5.20 mmol) of 4-aminopyridin-2(1H)-one, 500 mg (5.02 mmol) of pyrazole-3-carbaldehyde and 521 mg (5.20 mmol) of 2-cyanoethanethioamide were initially charged in 25 ml of 2-propanol, 0.45 ml (7.81 mmol) of acetic acid was added and the mixture was stirred at reflux for 48 h. The precipitate was removed by filtration, and the filtrate was evaporated and reacted further without further purification.

Workup

  1. temperatureat reflux for 48 h
  2. customThe precipitate was removed by filtration
  3. customthe filtrate was evaporated
  4. customreacted further without further purification

Sources & evidence

ORD record
ord-bee6aee1bea840cda572a3780c6b68ac
Source dataset
uspto-grants-2013_12
Patent number
US08618119B2

Reaction notes

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