Toluene → HCID 59447945, compound

HRID 1916301Notes

Reaction equation

HRID 1916301 reaction equation
[N:1]1[C:6]2[NH:7][C:8]3[CH:13]=[N:12][CH:11]=[CH:10][C:9]=3[C:5]=2[C:4](O)=[N:3][CH:2]=1.C(N(CC)CC)C.C1(C)C=CC=CC=1.O=P(Cl)(Cl)[Cl:31]>>[Cl:31][C:4]1[C:5]2[C:9]3[CH:10]=[CH:11][N:12]=[CH:13][C:8]=3[NH:7][C:6]=2[N:1]=[CH:2][N:3]=1

Participants

5

Reactant 4

HCID 1140TolueneHCID 8471TriethylamineHCID 24813Phosphorus oxychlorideHCID 178518050HCID 178518050, compound

Product 1

HCID 59447945HCID 59447945, compound

Conditions

Temperature
75 °C

Procedure

A mixture of 9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-4-ol (264 mg, 1.4 mmol) and triethylamine (750 μL) in 5 mL POCl3 was heated at 75° C. for 18 hours. Toluene was added to the cooled reaction mixture and the solvents were then removed in vacuo to give the title compound as a brown oil (290 mg). LC-MS (1) Rt 1.25 min; m/z (ES+) 205/207.

Workup

  1. customthe solvents were then removed in vacuo

Sources & evidence

ORD record
ord-eab0c81f94e14ca9a8a30027f677b1be
Source dataset
uspto-grants-2013_12
Patent number
US08618121B2

Reaction notes

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