反应详情

To 1H-imidazole-2-carboaldehyde (2.0 g), N-methylpyrrolidone (25 mL) was added, followed by dissolution with heating. To the resultant solution, ethyl chloroacetate (11.1 mL) and potassium carbonate (2.9 g) were added. The reaction solution was stirred at room temperature for 14 hours. To the reaction solution, water (30 mL) was added. The aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, washed with saturated saline and then dried over anhydrous sodium sulfate. The anhydrous sodium sulfate was removed by filtration and the solvent was concentrated under reduced pressure. The residue was purified by silica gel chromatography (dichloromethane) to obtain the title compound having the following physical properties (1.3 g).

1. dissolutionfollowed by dissolution
2. temperaturewith heating
3. extractionThe aqueous layer was extracted twice with ethyl acetate
4. washwashed with saturated saline
5. dry with materialdried over anhydrous sodium sulfate
6. customThe anhydrous sodium sulfate was removed by filtration
7. concentrationthe solvent was concentrated under reduced pressure
8. customThe residue was purified by silica gel chromatography (dichloromethane)