反应详情

A mixture of ethyl 4,5-dihydro-3,5-dimethyl-1H-pyrazole-1-acetate (i.e. the product of Step A) (0.26 g, 0.0014 mol) and lithium hydroxide (0.072 g, 3 mmol) in a solution of methanol (2 mL), tetrahydrofuran (2 mL) and water (2 mL) was stirred overnight at room temperature. Saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was concentrated under reduced pressure. The resulting residue was dissolved in ethyl acetate, and the organic layer was concentrated under reduced pressure to provide the title compound as a colorless oil (0.10 g).

1. concentrationthe mixture was concentrated under reduced pressure
2. dissolutionThe resulting residue was dissolved in ethyl acetate
3. concentrationthe organic layer was concentrated under reduced pressure