1-Methylpiperazine → 5-Bromo-2-(4-methylpiperazin-1-yl)pyridine

HRID 1916582Notes

Reaction equation

HRID 1916582 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](I)=[N:6][CH:7]=1.[CH3:9][N:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:13]2[CH2:14][CH2:15][N:10]([CH3:9])[CH2:11][CH2:12]2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 5936905-Bromo-2-iodopyridine

Product 1

HCID 164142065-Bromo-2-(4-methylpiperazin-1-yl)pyridine

Procedure

The product is obtained analogously to Example 3.24a is from 1.5 g (5.28 mmol) 5-bromo-2-iodopyridine and 1.3 mL (11.7 mmol) N-methylpiperazine.

Workup

  1. customThe product is obtained analogously to Example 3.24a

Sources & evidence

ORD record
ord-570f9e1a30774626a68a85b244e42e84
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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