Potassium Carbonate → HCID 67363753, compound

HRID 1916610Notes

Reaction equation

HRID 1916610 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]([NH:8][CH2:9][CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:6][CH:7]=1.[C:17]([O-])([O-])=O.[K+].[K+]>C(O)=O>[Br:1][C:2]1[CH:3]=[C:4]2[N:16]=[CH:17][N:8]([CH2:9][CH2:10][N:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)[C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 62640828HCID 62640828, compound

Product 1

HCID 67363753HCID 67363753, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of 470 mg (1.65 mmol) 5-bromo-N2-(2-pyrrolidin-1-yl-ethyl)-pyridine-2,3-diamine in 10 mL formic acid is refluxed for 1.5 h. The mixture is made alkaline with saturated K2CO3 solution and extracted with 40 mL EtOAc. The organic phase is dried over Na2SO4 and the solvent is eliminated i.vac.

Workup

  1. extractionextracted with 40 mL EtOAc
  2. dry with materialThe organic phase is dried over Na2SO4

Sources & evidence

ORD record
ord-145ecbdc1fb34f3ba9e782d0da06c36a
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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