Pyrrolidine → HCID 178526483, compound

HRID 1916614Notes

Reaction equation

HRID 1916614 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:7][C:8]1[NH:12][C:11]2[CH:13]=[CH:14][C:15]([N+:17]([O-:19])=[O:18])=[CH:16][C:10]=2[N:9]=1>C(Cl)Cl>[N+:17]([C:15]1[CH:14]=[CH:13][C:11]2[NH:12][C:8]([CH2:7][N:1]3[CH2:5][CH2:4][CH2:3][CH2:2]3)=[N:9][C:10]=2[CH:16]=1)([O-:19])=[O:18]

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 178526480HCID 178526480, compound

Product 1

HCID 178526483HCID 178526483, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

9.47 mL (113 mmol) pyrrolidine are added to a solution of 6.00 g (28.4 mmol) 2-chloromethyl-5-nitro-1H-benzimidazole in 100 mL DCM. The reaction is stirred overnight at RT. The reaction solution is washed four times with water. The organic phase is dried over MgSO4 and the solvent is eliminated i.vac.

Workup

  1. washThe reaction solution is washed four times with water
  2. dry with materialThe organic phase is dried over MgSO4

Sources & evidence

ORD record
ord-443753b4887d4a4e8c1b4c47b74bec25
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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