Pyrrolidine → HCID 2824673, compound

HRID 1916650Notes

Reaction equation

HRID 1916650 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Cl[CH2:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([I:17])=[CH:13][CH:12]=1)=[O:9]>C(Cl)Cl>[I:17][C:14]1[CH:13]=[CH:12][C:11]([NH:10][C:8](=[O:9])[CH2:7][N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 7357922-chloro-N-(4-iodophenyl)acetamide

Product 1

HCID 2824673HCID 2824673, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1.53 mL (18.6 mmol) pyrrolidine are added to a solution of 2.20 g (7.45 mmol) 2-chloro-N-(4-iodo-phenyl)-acetamide in 50 mL DCM. The reaction solution is stirred overnight at RT. The mixture is filtered, the filtrate dried over MgSO4 and the solvent is eliminated i.vac.

Workup

  1. filtrationThe mixture is filtered
  2. dry with materialthe filtrate dried over MgSO4

Sources & evidence

ORD record
ord-9eece8b3b1a648989db2fec8935feae1
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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