Trifluoroacetic acid → HCID 59835824, compound

HRID 1916697Notes

Reaction equation

HRID 1916697 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[C:22][C:23]3[CH:46]=[CH:45][C:26]([O:27][CH2:28][CH2:29][N:30]([CH3:44])[CH:31]4[CH2:36][CH2:35][N:34](C(OC(C)(C)C)=O)[CH2:33][CH2:32]4)=[CH:25][CH:24]=3)=[N:19][CH:20]=2)=[CH:11][CH:10]=1>C(Cl)Cl>[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]#[C:22][C:23]3[CH:24]=[CH:25][C:26]([O:27][CH2:28][CH2:29][N:30]([CH3:44])[CH:31]4[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]4)=[CH:45][CH:46]=3)=[N:19][CH:20]=2)=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69070497HCID 69070497, compound

Product 1

HCID 59835824HCID 59835824, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

60 μL (0.8 mmol) trifluoroacetic acid are added to a solution of 22 mg (0.04 mmol) tert-butyl 4-[(2-{4-[5-(4-chloro-phenyl)-pyridin-2-ylethynyl]-phenoxy}-ethyl)-methyl-amino]-piperidin-1-carboxylate in 5 mL DCM and the reaction mixture is stirred for 24 h at RT. The mixture is evaporated down i. vac. and the residue is stirred with diethyl ether. The precipitate is suction filtered, washed with diethyl ether and dried.

Workup

  1. customThe mixture is evaporated down i
  2. stirringand the residue is stirred with diethyl ether
  3. filtrationfiltered
  4. washwashed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-8d34fc7537944a3f9c9b37c5eae98772
Source dataset
uspto-grants-2013_12
Patent number
US08618132B2

Reaction notes

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