HCID 67954034, compound → HCID 67953928, compound

HRID 1916871Notes

Reaction equation

HRID 1916871 reaction equation
C(OC([N:8]([C:22]1[N:23]=[C:24]2[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][N:25]2[C:31]=1[CH3:32])[S:9]([C:12]1[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=1)(=[O:11])=[O:10])=O)(C)(C)C>Cl.O1CCOCC1>[ClH:30].[Cl:30][C:27]1[CH:28]=[CH:29][C:24]2[N:25]([C:31]([CH3:32])=[C:22]([NH:8][S:9]([C:12]3[CH:21]=[CH:20][C:15]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][CH:13]=3)(=[O:11])=[O:10])[N:23]=2)[CH:26]=1

Participants

4

Reactant 1

HCID 67954034HCID 67954034, compound

Product 1

HCID 67953928HCID 67953928, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

Compound 15-C (0.820 g, 1.71 mmol) was dissolved in 4N HCl in dioxane (44 mL) and the reaction mixture was stirred for 24 h at room temperature. The solvent was evaporated in vacuo and the crude product was washed with ethyl ether. The resulting solid was filtered, washed with additional ethyl ether, and dried in vacuo to give compound 15-D as a white solid (0.610 g, 86%); MS m/z (M+H+) 380.

Workup

  1. customThe solvent was evaporated in vacuo
  2. washthe crude product was washed with ethyl ether
  3. filtrationThe resulting solid was filtered
  4. washwashed with additional ethyl ether
  5. customdried in vacuo
  6. customto give compound 15-D as a white solid (0.610 g, 86%)

Sources & evidence

ORD record
ord-7489e250853549ada7c4055f4656b305
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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