Hydrochloric Acid → HCID 67953981, compound

HRID 1916876Notes

Reaction equation

HRID 1916876 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][N:6]2[C:9]([CH3:20])=[C:10]([NH:12]C(=O)OC(C)(C)C)[N:11]=[C:5]2[CH:4]=1.[ClH:23]>O1CCOCC1>[ClH:23].[NH2:12][C:10]1[N:11]=[C:5]2[CH:4]=[C:3]([C:2]([F:22])([F:1])[F:21])[CH:8]=[CH:7][N:6]2[C:9]=1[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90090780HCID 90090780, compound

Product 1

HCID 67953981HCID 67953981, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound 17-C (0.221 g, 0.7 mmol) was dissolved in 4N HCl in dioxane (7 mL) and the reaction mixture was stirred for 2 h at room temperature. The solvent was evaporated in vacuo to give compound 17-D as a light yellow solid; MS m/z (M+H+) 216.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customto give compound 17-D as a light yellow solid

Sources & evidence

ORD record
ord-31f544e6c15149adac5c8925417dd826
Source dataset
uspto-grants-2013_12
Patent number
US08618150B2

Reaction notes

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