Acetic Acid Mixture with Hydrobromic Acid → Hydrogen Bromide

HRID 1917080Notes

Reaction equation

HRID 1917080 reaction equation
[F:1][C:2]([F:26])([F:25])[O:3][C:4]1[CH:5]=[CH:6][C:7]2[S:13][CH2:12][CH2:11][N:10](C(OCC3C=CC=CC=3)=O)[CH2:9][C:8]=2[CH:24]=1.[BrH:27].CC(O)=O>C(OCC)C>[BrH:27].[F:26][C:2]([F:1])([F:25])[O:3][C:4]1[CH:5]=[CH:6][C:7]2[S:13][CH2:12][CH2:11][NH:10][CH2:9][C:8]=2[CH:24]=1.[BrH:27]

Participants

5

Reactant 2

HCID 21893785Acetic Acid Mixture with Hydrobromic AcidHCID 57864657HCID 57864657, compound

Product 2

HCID 260Hydrogen BromideHCID 68637628HCID 68637628, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The starting material 30 (200 mg) was treated with 3 mL of HBr/AcOH solution for 1 h. To the reaction mixture was added diethyl ether (20 mL). The white solid was filtered to give the title compound as HBr salt. Yield: 182 mg.

Workup

  1. filtrationThe white solid was filtered

Sources & evidence

ORD record
ord-8c15644a12924d57831855c45c029709
Source dataset
uspto-grants-2013_12
Patent number
US08618282B2

Reaction notes

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